OSBL6 Antibody - #DF12514

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Product: OSBL6 Antibody
Catalog: DF12514
Description: Rabbit polyclonal antibody to OSBL6
Application: WB
Reactivity: Human
Prediction: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 106 kDa; 106kD(Calculated).
Uniprot: Q9BZF3
RRID: AB_2845476

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(89%)
Clonality:
Polyclonal
Specificity:
OSBL6 Antibody detects endogenous levels of total OSBL6.
RRID:
AB_2845476
Cite Format: Affinity Biosciences Cat# DF12514, RRID:AB_2845476.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FLJ36583; ORP 6; ORP-6; ORP6; OSBL6_HUMAN; OSBP-related protein 6; OSBPL 6; Osbpl6; Oxysterol Binding Protein like 6; Oxysterol-binding protein-related protein 6;

Immunogens

Immunogen:
Uniprot:

Q9BZF3(OSBL6_HUMAN) >>Visit HPA database.

Gene(ID):
OSBPL6(114880)
Expression:
Q9BZF3 OSBL6_HUMAN:

Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528).

Sequence:
MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQSIHILERTASSSTEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQTNVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Zebrafish
100
Chicken
100
Rabbit
100
Xenopus
89
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9BZF3 As Substrate

Site PTM Type Enzyme
S2 Acetylation
S2 Phosphorylation
S9 Phosphorylation
S15 Phosphorylation
S32 Phosphorylation
S35 Phosphorylation
T42 Phosphorylation
S44 Phosphorylation
S50 Phosphorylation
S133 Phosphorylation
S190 Phosphorylation
S195 Phosphorylation
S229 Phosphorylation
S290 Phosphorylation
S337 Phosphorylation
T356 Phosphorylation
S413 Phosphorylation
S428 Phosphorylation
K581 Ubiquitination
S704 Phosphorylation
T712 Phosphorylation
Y746 Phosphorylation
Y802 Phosphorylation
K872 Ubiquitination
S926 Phosphorylation

Research Backgrounds

Function:

Regulates cellular transport and efflux of cholesterol. Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol.

Subcellular Location:

Cytoplasm>Cytosol. Endoplasmic reticulum membrane>Peripheral membrane protein. Nucleus envelope. Cell membrane>Peripheral membrane protein. Endosome membrane>Peripheral membrane protein.
Note: Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in brain and striated muscle (at protein level). Widely expressed. Expressed in skeletal muscle.

Subunit Structure:

Homodimer (By similarity). Interacts with OSBPL3 (By similarity).

Family&Domains:

Belongs to the OSBP family.

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