AUP1 Antibody - #DF12566
| Product: | AUP1 Antibody |
| Catalog: | DF12566 |
| Description: | Rabbit polyclonal antibody to AUP1 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 40 kDa; 46kD(Calculated). |
| Uniprot: | Q9Y679 |
| RRID: | AB_2845528 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12566, RRID:AB_2845528.
Fold/Unfold
AA589454; Ancient ubiquitous protein 1; AUP 1; aup1; AUP1_HUMAN;
Immunogens
Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.
- Q9Y679 AUP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELPSGPGPERLFDSHRLPGDCFLLLVLLLYAPVGFCLLVLRLFLGIHVFLVSCALPDSVLRRFVVRTMCAVLGLVARQEDSGLRDHSVRVLISNHVTPFDHNIVNLLTTCSTPLLNSPPSFVCWSRGFMEMNGRGELVESLKRFCASTRLPPTPLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLRPVHRQLGEANEEFALRVQQLVAKELGQTGTRLTPADKAEHMKRQRHPRLRPQSAQSSFPPSPGPSPDVQLATLAQRVKEVLPHVPLGVIQRDLAKTGCVDLTITNLLEGAVAFMPEDITKGTQSLPTASASKFPSSGPVTPQPTALTFAKSSWARQESLQERKQALYEYARRRFTERRAQEAD
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y679 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| T68 | Phosphorylation | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| T154 | Phosphorylation | Uniprot | |
| K250 | Ubiquitination | Uniprot | |
| T260 | Phosphorylation | Uniprot | |
| K264 | Ubiquitination | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| S280 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| S288 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| K322 | Ubiquitination | Uniprot | |
| K347 | Ubiquitination | Uniprot | |
| S356 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| T367 | Phosphorylation | Uniprot | |
| T371 | Phosphorylation | Uniprot | |
| K377 | Ubiquitination | Uniprot | |
| S385 | Phosphorylation | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| Y394 | Phosphorylation | Uniprot | |
| Y396 | Phosphorylation | Uniprot |
Research Backgrounds
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.
Endoplasmic reticulum membrane>Single-pass type III membrane protein>Cytoplasmic side.
Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.
Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM.
Belongs to the AUP1 family.
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