DMKN Antibody - #DF12597
| Product: | DMKN Antibody |
| Catalog: | DF12597 |
| Description: | Rabbit polyclonal antibody to DMKN |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Sheep |
| Mol.Wt.: | 48 kDa; 47kD(Calculated). |
| Uniprot: | Q6E0U4 |
| RRID: | AB_2845559 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12597, RRID:AB_2845559.
Fold/Unfold
Dermokine; DMKN; DMKN_HUMAN; Epidermis-specific secreted protein SK30/SK89; FLJ79374; UNQ729; UNQ729/PRO1411; ZD52F10;
Immunogens
Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta. Isoform 1 is expressed in epidermis.
- Q6E0U4 DMKN_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGVADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTFWKNFKSKLGFINWDAINKNQVPPPSTRALLYFSRLWEDFKQNTPFLNWKAIIEGADASSLQKRAGRDDQNYNYNQHAYPTAYGGKYSVKTPAKGGVSPSSSASRVQPGLLQWVKFW
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6E0U4 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T109 | O-Glycosylation | Uniprot | |
| K445 | Ubiquitination | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| T450 | Phosphorylation | Uniprot |
Research Backgrounds
May act as a soluble regulator of keratinocyte differentiation.
O-glycosylated.
Secreted.
Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta. Isoform 1 is expressed in epidermis.
Homooligomer. Seems to be able to homodimerize and homotrimerize.
Belongs to the dermokine family.
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