IgG4 Antibody - #DF12638
| Product: | IgG4 Antibody |
| Catalog: | DF12638 |
| Description: | Rabbit polyclonal antibody to IgG4 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Mol.Wt.: | 52 kDa; 36kD(Calculated). |
| Uniprot: | P01861 |
| RRID: | AB_2845600 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12638, RRID:AB_2845600.
Fold/Unfold
AU044919; Gamma 2b immunoglobulin; Ig gamma 4 chain C region; Ighg 4; Ighg4; Immunoglobulin gamma 4 heavy chain; Immunoglobulin heavy chain (gamma polypeptide 4); Immunoglobulin heavy chain gamma polypeptide; Immunoglobulin heavy constant gamma 4 (G4m marker); MGC102604; MGC102659;
Immunogens
- P01861 IGHG4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
PTMs - P01861 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T18 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| T22 | Phosphorylation | Uniprot | |
| T130 | Phosphorylation | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| N177 | N-Glycosylation | Uniprot | |
| S244 | Phosphorylation | Uniprot | |
| T246 | Phosphorylation | Uniprot |
Research Backgrounds
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Secreted. Cell membrane.
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
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