LDB3 Antibody - #DF12652
| Product: | LDB3 Antibody |
| Catalog: | DF12652 |
| Description: | Rabbit polyclonal antibody to LDB3 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 32/78 kDa; 77kD(Calculated). |
| Uniprot: | O75112 |
| RRID: | AB_2845614 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12652, RRID:AB_2845614.
Fold/Unfold
CMD1C; CYPHER; HGNC:15710; KIAA01613; KIAA0613; Ldb3; LDB3_HUMAN; LDB3Z1; LDB3Z4; LIM domain binding 3; LIM domain binding protein 3; LIM domain-binding protein 3; LVNC3; ORACLE; PDLIM6; PDZ and LIM domain 6; Protein cypher; Z band alternatively spliced PDZ motif; Z band alternatively spliced PDZ motif protein; Z-band alternatively spliced PDZ-motif protein; ZASP;
Immunogens
Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.
- O75112 LDB3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAPSPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSSTPIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTINL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O75112 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| K21 | Sumoylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| Y74 | Phosphorylation | Uniprot | |
| T98 | Phosphorylation | Uniprot | |
| T113 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| Y202 | Phosphorylation | Uniprot | |
| S243 | Phosphorylation | Uniprot | |
| Y246 | Phosphorylation | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| T513 | Phosphorylation | Uniprot | |
| Y521 | Phosphorylation | Uniprot | |
| Y579 | Phosphorylation | Uniprot | |
| Y656 | Phosphorylation | Uniprot | |
| Y661 | Phosphorylation | Uniprot | |
| S666 | Phosphorylation | Uniprot | |
| T667 | Phosphorylation | Uniprot | |
| K712 | Acetylation | Uniprot | |
| K713 | Acetylation | Uniprot |
Research Backgrounds
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
Cytoplasm>Perinuclear region. Cell projection>Pseudopodium. Cytoplasm>Cytoskeleton. Cytoplasm>Myofibril>Sarcomere>Z line.
Note: Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.
Interacts via its LIM domains with various PKC isoforms (By similarity). Interacts via its PDZ domain with the ACTN2 C-terminal region. Interacts with MYOZ1, MYOZ2 and MYOZ3.
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