MXD1 Antibody - #DF12664
| Product: | MXD1 Antibody |
| Catalog: | DF12664 |
| Description: | Rabbit polyclonal antibody to MXD1 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 25 kDa; 25kD(Calculated). |
| Uniprot: | Q05195 |
| RRID: | AB_2845626 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12664, RRID:AB_2845626.
Fold/Unfold
MAD; MAD protein; MAD1; MAD1_HUMAN; MAX dimerization protein 1; Max dimerizer 1; Mxd1; Protein MAD;
Immunogens
- Q05195 MAD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSSSSVSDSDERGSMQSLGSDEGYSSTSIKRIKLQDSHKACLGL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q05195 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K39 | Acetylation | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| T94 | Phosphorylation | Uniprot | |
| S96 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| K135 | Ubiquitination | Uniprot | |
| S145 | Phosphorylation | Q15418 (RPS6KA1) , Q9UBS0 (RPS6KB2) , P23443 (RPS6KB1) , P31749 (AKT1) | Uniprot |
| R189 | Methylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| Y201 | Phosphorylation | Uniprot |
Research Backgrounds
Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.
Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome.
Nucleus.
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17 (By similarity).
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