NCS1 Antibody - #DF12665
| Product: | NCS1 Antibody |
| Catalog: | DF12665 |
| Description: | Rabbit polyclonal antibody to NCS1 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Dog, Chicken, Xenopus |
| Mol.Wt.: | 22 kDa; 22kD(Calculated). |
| Uniprot: | P62166 |
| RRID: | AB_2845627 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12665, RRID:AB_2845627.
Fold/Unfold
9430075O15Rik; A730032G13Rik; AI836659; DKFZp761L1223; FLUP; FREQ; Frequenin; Frequenin homolog (Drosophila); Frequenin homolog; Frequenin like protein; Frequenin, Drosophila, homolog of; Frequenin-like protein; Frequenin-like ubiquitous protein; Mfreq; NCS 1; NCS-1; ncs1; NCS1_HUMAN; Neuronal calcium sensor 1; Neuronal Calicum Sensor 1;
Immunogens
- P62166 NCS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P62166 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| K25 | Ubiquitination | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K53 | Sumoylation | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| Y108 | Phosphorylation | Uniprot | |
| Y115 | Phosphorylation | Uniprot | |
| T117 | Phosphorylation | Uniprot | |
| T144 | Phosphorylation | Uniprot |
Research Backgrounds
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).
Golgi apparatus. Cell junction>Synapse>Postsynaptic density. Cytoplasm>Perinuclear region. Cytoplasm. Cell membrane>Peripheral membrane protein. Membrane>Lipid-anchor.
Note: Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.
Monomer (By similarity). Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB (By similarity). This binding competes with CALN2/CABP7 binding to PI4KB (By similarity). Interacts in a calcium-dependent manner with PICK1 (via AH domain) (By similarity). Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts with IL1RAPL1.
Belongs to the recoverin family.
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