OSBPL2 Antibody - #DF12681
| Product: | OSBPL2 Antibody |
| Catalog: | DF12681 |
| Description: | Rabbit polyclonal antibody to OSBPL2 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Sheep |
| Mol.Wt.: | 56 kDa; 55kD(Calculated). |
| Uniprot: | Q9H1P3 |
| RRID: | AB_2845643 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12681, RRID:AB_2845643.
Fold/Unfold
FLJ20223; KIAA0772; MGC4307; MGC8342; ORP2; OSBP related protein 2; Oxysterol binding protein like 2; Oxysterol binding protein related protein 2;
Immunogens
- Q9H1P3 OSBL2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNGEEEFFDAVTGFDSDNSSGEFSEANQKVTGMIDLDTSKNNRIGKTGERPSQENGIQKHRTSLPAPMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKLFMIYGKWTECLWGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQVIPGSKLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQREARRERAKEEAEWQTRWFYPGNNPYTGTPDWLYAGDYFERNFSDCPDIY
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H1P3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S19 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| T47 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K282 | Ubiquitination | Uniprot | |
| K361 | Ubiquitination | Uniprot | |
| K439 | Ubiquitination | Uniprot | |
| S474 | Phosphorylation | Uniprot |
Research Backgrounds
Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro).
Cytoplasm>Cytosol. Lipid droplet. Cell membrane>Peripheral membrane protein>Cytoplasmic side.
Note: Detected on the surface of cytosolic lipid droplets (PubMed:19224871). Recruited to the cell membrane by phosphatidylinositol-phosphate binding (PubMed:30581148).
Widely expressed.
Monomer. Homotetramer; phosphatidylinositol-4,5-bisphosphate binding promotes formation of stable tetramers. Interacts with DIAPH1.
Belongs to the OSBP family.
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