RARG Antibody - #DF12718
| Product: | RARG Antibody |
| Catalog: | DF12718 |
| Description: | Rabbit polyclonal antibody to RARG |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Dog |
| Mol.Wt.: | 50 kDa; 50kD(Calculated). |
| Uniprot: | P13631 |
| RRID: | AB_2845679 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12718, RRID:AB_2845679.
Fold/Unfold
NR1B3; Nuclear receptor subfamily 1 group B member 3; RAR gamma; RAR gamma isoform 2; RAR gamma2; RAR-gamma; RARC; Rarg; RARG_HUMAN; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; Retinoic acid receptor gamma;
Immunogens
- P13631 RARG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P13631 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S36 | Phosphorylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | P27361 (MAPK3) , P35269 (GTF2F1) , P50613 (CDK7) | Uniprot |
| S79 | Phosphorylation | P50613 (CDK7) , P35269 (GTF2F1) , P27361 (MAPK3) | Uniprot |
| K120 | Ubiquitination | Uniprot | |
| K172 | Sumoylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| S452 | Phosphorylation | Uniprot |
Research Backgrounds
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
Nucleus. Cytoplasm.
Expressed in aortic endothelial cells (at protein level).
Homodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus.
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Belongs to the nuclear hormone receptor family. NR1 subfamily.
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