RHOT2 Antibody - #DF12721
| Product: | RHOT2 Antibody |
| Catalog: | DF12721 |
| Description: | Rabbit polyclonal antibody to RHOT2 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| Mol.Wt.: | 68 kDa; 68kD(Calculated). |
| Uniprot: | Q8IXI1 |
| RRID: | AB_2845682 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12721, RRID:AB_2845682.
Fold/Unfold
ARHT2; C16orf39; hMiro 2; hMiro-2; hMiro2; MIRO-2; MIRO2_HUMAN; Mitochondrial Rho GTPase 2; Ras homolog gene family member T2; RASL; RHOT2;
Immunogens
Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.
- Q8IXI1 MIRO2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTDEELREEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEAVLPIMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQALSDEELNAFQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRGRHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGALSPVELQSLFSVFPAAPWGPELPRTVRTEAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYPTLCEQDQAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQDTREQPPGYAIDTVQVNGQEKYLILCEVGTDGLLATSLDATCDVACLMFDGSDPKSFAHCASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQLATMAAFPHLVHAELHPSSFWLRGLLGVVGAAVAAVLSFSLYRVLVKSQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8IXI1 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K50 | Ubiquitination | Uniprot | |
| Y58 | Phosphorylation | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| T64 | Phosphorylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| Y160 | Phosphorylation | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| K420 | Ubiquitination | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| S506 | Phosphorylation | Uniprot | |
| K509 | Ubiquitination | Uniprot | |
| T517 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| K525 | Ubiquitination | Uniprot | |
| C543 | S-Nitrosylation | Uniprot |
Research Backgrounds
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
Mitochondrion outer membrane>Single-pass type IV membrane protein.
Note: Colocalizes with MGARP and RHOT2 at the mitochondria.
Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.
Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules. Interacts with ARMCX3 (By similarity). Found in a complex with KIF5B, OGT, RHOT1 and TRAK1.
Belongs to the mitochondrial Rho GTPase family.
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