SUZ12 Antibody - #DF12759
| Product: | SUZ12 Antibody |
| Catalog: | DF12759 |
| Description: | Rabbit polyclonal antibody to SUZ12 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 85 kDa; 83kD(Calculated). |
| Uniprot: | Q15022 |
| RRID: | AB_2845720 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12759, RRID:AB_2845720.
Fold/Unfold
ChET 9 protein; CHET9; Chromatin precipitated E2F target 9 protein; JJAZ1; Joined to JAZF1 protein; KIAA0160; Polycomb protein SUZ12; Suppressor of zeste 12 homolog; Suppressor of zeste 12 protein homolog; SUZ12; SUZ12 polycomb repressive complex 2 subunit; SUZ12_HUMAN;
Immunogens
- Q15022 SUZ12_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15022 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K5 | Methylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| K72 | Sumoylation | Uniprot | |
| K73 | Sumoylation | Uniprot | |
| K75 | Sumoylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| T131 | Phosphorylation | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| K140 | Acetylation | Uniprot | |
| K140 | Sumoylation | Uniprot | |
| K143 | Acetylation | Uniprot | |
| K145 | Acetylation | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| K223 | Sumoylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| K246 | Acetylation | Uniprot | |
| Y248 | Phosphorylation | Uniprot | |
| T255 | Phosphorylation | Uniprot | |
| T336 | Phosphorylation | Uniprot | |
| K341 | Acetylation | Uniprot | |
| K341 | Ubiquitination | Uniprot | |
| K368 | Ubiquitination | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| T379 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| K403 | Methylation | Uniprot | |
| T412 | Phosphorylation | Uniprot | |
| K414 | Methylation | Uniprot | |
| T418 | Phosphorylation | Uniprot | |
| K537 | Ubiquitination | Uniprot | |
| S539 | Phosphorylation | P53350 (PLK1) | Uniprot |
| S541 | Phosphorylation | P53350 (PLK1) | Uniprot |
| S546 | Phosphorylation | P53350 (PLK1) | Uniprot |
| S568 | Phosphorylation | Uniprot | |
| T570 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| K595 | Ubiquitination | Uniprot | |
| S604 | Phosphorylation | Uniprot | |
| K687 | Ubiquitination | Uniprot | |
| S693 | Phosphorylation | Uniprot | |
| S695 | Phosphorylation | Uniprot | |
| T724 | Phosphorylation | Uniprot | |
| S726 | Phosphorylation | Uniprot |
Research Backgrounds
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Sumoylated, probably by PIAS2.
Nucleus.
Overexpressed in breast and colon cancer.
Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with WDR77. Interacts with histone H1. Interacts with CDYL. Interacts with ARNTL/BMAL1. Interacts with EZHIP (via C-terminal region).
Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
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