TALPID3 Antibody - #DF12765

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Product: TALPID3 Antibody
Catalog: DF12765
Description: Rabbit polyclonal antibody to TALPID3
Application: WB
Reactivity: Human, Mouse, Monkey
Mol.Wt.: 169 kDa; 169kD(Calculated).
Uniprot: Q9BVV6
RRID: AB_2845726

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Monkey
Clonality:
Polyclonal
Specificity:
TALPID3 Antibody detects endogenous levels of total TALPID3.
RRID:
AB_2845726
Cite Format: Affinity Biosciences Cat# DF12765, RRID:AB_2845726.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Immunogens

Immunogen:
Uniprot:

Q9BVV6(TALD3_HUMAN) >>Visit HPA database.

Gene(ID):
KIAA0586(9786)
Expression:
Q9BVV6 TALD3_HUMAN:

Ubiquitously expressed (PubMed:26386044). Expressed in photoreceptor cells (at protein level) (PubMed:26386247).

Sequence:
MPVKRLREVVSQNHGDHLVLLKDELPCVPPALSANKRLPVGTGTSLNGTSRGSSDLTSARNCYQPLLENPMVSESDFSKDVAVQVLPLDKIEENNKQKANDIFISQYTMGQKDALRTVLKQKAQSMPVFKEVKVHLLEDAGIEKDAVTQETRISPSGIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNSVTELLSKLQETDKHLQRVTEQQTSIQRKQEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISAALKTSSFQPVSMPSSRAVEKYSVKPEHPNLGSCNPSLYNTFASKQAPLKEVEDTSFDKQKSPLETPAPRRFAPVPVSRDDELSKRENLLEEKENMEVSCHRGNVRLLEQILNNNDSLTRKSESSNTTSLTRSKIGWTPEKTNRFPSCEELETTKVTMQKSDDVLHDLGQKEKETNSMVQPKESLSMLKLPDLPQNSVKLQTTNTTRSVLKDAEKILRGVQNNKKVLEENLEAIIRAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAEIQDELSRTDYEQKRFDQKNQRTKKGQNMTKDIRTNTQDKTVNKSVIPRKHSQKQIEEHFRNLPMRGMPASSLQKERKEGLLKATTVIQDEDYMLQVYGKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYATKPKKMDSKMKHSVPVLPHGDQQYLFSPSREMPTFSGTLEGHLIPMAILLGQTQSNSDTMPPAGVIVSKPHPVTVTTSIPPSSRKVETGVKKPNIAIVEMKSEKKDPPQLTVQVLPSVDIDSISNSSADVLSPLSSPKEASLPPVQTWIKTPEIMKVDEEEVKFPGTNFDEIIDVIQEEEKCDEIPDSEPILEFNRSVKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSLIQWVEQEIMSRIISGLFPVQQQIAPSISVSVSETSEPLTSDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAVMLGDREAKKQGPVATGVSGDASTNETYLPARVCTPLPTPQPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMAFPVKEICAEKGDDMPAIMLVNTPTVTPTTTPPPAAAVFTPTLSDISIDKLKVSSPELPKPWGDGDLPLEEENPNSPQEELHPRAIVMSVAKDEEPESMDFPAQPPPPEPVPFMPFPAGTKAPSPSQMPGSDSSTLESTLSVTVTETETLDKPISEGEILFSCGQKLAPKILEDIGLYLTNLNDSLSSTLHDAVEMEDDPPSEGQVIRMSHKKFHADAILSFAKQNQESAVSQQAVYHSEDLENSVGELSEGQRPQLTAAAENILMGHSLYMQPPVTNTQSLDQQCDPKPLSRQFDTVSGSIYEDSCASHGPMSLGELELEPNSKLVLPTTLLTAQENDVNLPVAAEDFSQYQLKQNQDVKQVEHKPSQSYLRVRNKSDIAPSQQQVSPGDMDRTQIELNPYLTCVFSGGKAVPLSASQMPPAKMSVMLPSVNLEDCSQSLSLSTMQEDMESSGADTF

PTMs - Q9BVV6 As Substrate

Site PTM Type Enzyme
S73 Phosphorylation
S78 Phosphorylation
S125 Phosphorylation
K144 Ubiquitination
S183 Phosphorylation
K188 Ubiquitination
S191 Phosphorylation
K198 Ubiquitination
K204 Ubiquitination
K304 Ubiquitination
S321 Phosphorylation
S343 Phosphorylation
K352 Ubiquitination
S358 Phosphorylation
S376 Phosphorylation
K380 Ubiquitination
K393 Ubiquitination
K400 Ubiquitination
T401 Phosphorylation
S406 Phosphorylation
T413 Phosphorylation
K414 Ubiquitination
K448 Ubiquitination
K458 Ubiquitination
K484 Ubiquitination
K497 Ubiquitination
S516 Phosphorylation
K523 Ubiquitination
K588 Ubiquitination
S605 Phosphorylation
S606 Phosphorylation
K609 Ubiquitination
K634 Ubiquitination
S654 Phosphorylation
S656 Phosphorylation
S659 Phosphorylation
Y685 Phosphorylation
T687 Phosphorylation
K688 Ubiquitination
Y710 Phosphorylation
S713 Phosphorylation
S715 Phosphorylation
S818 Phosphorylation
S827 Phosphorylation
K1013 Ubiquitination
S1129 Phosphorylation
S1130 Phosphorylation
S1151 Phosphorylation
S1296 Phosphorylation
S1501 Phosphorylation
S1506 Phosphorylation

Research Backgrounds

Function:

Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation. Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity).

Subcellular Location:

Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Photoreceptor inner segment. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole. Cytoplasm>Cytoskeleton>Cilium basal body.
Note: Forms a ring-like structure at the extreme distal end of both mother and daughter centrioles (PubMed:24421332). In photoreceptor cells localized to the joint between the inner and outer segments, specifically localized at the mother centriole (basal body) and the adjacent centriole as well as between the two centrioles but not in the connecting cilium (PubMed:26386247).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitously expressed. Expressed in photoreceptor cells (at protein level).

Subunit Structure:

Interacts with CCP110, CEP290, CEP97, KIF24.

Family&Domains:

Belongs to the TALPID3 family.

Restrictive clause

 

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