TESC Antibody - #DF12769
| Product: | TESC Antibody |
| Catalog: | DF12769 |
| Description: | Rabbit polyclonal antibody to TESC |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Rabbit, Dog |
| Mol.Wt.: | 25 kDa; 25kD(Calculated). |
| Uniprot: | Q96BS2 |
| RRID: | AB_2845730 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12769, RRID:AB_2845730.
Fold/Unfold
1010001A17Rik; Calcineurin B homologous protein 3; CHP3; FLJ20607; MGC117906; OTTHUMP00000185561; OTTMUSP00000023573; TE 1; Tescalcin; TSC;
Immunogens
Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
- Q96BS2 CHP3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPIDTTMDEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCMGQMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96BS2 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| S156 | Phosphorylation | Uniprot |
Research Backgrounds
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Nucleus. Cytoplasm. Membrane>Lipid-anchor. Cell membrane. Cell projection>Lamellipodium. Cell projection>Ruffle membrane.
Note: Colocalizes with SLC9A1 at the plasma membrane.
Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
Monomer (By similarity). Homodimer; disulfide-linked (By similarity). Interacts with SLC9A1/NHE1; the interaction enables an optimal Na(+)/H(+) exchange activity.
Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium (By similarity).
Belongs to the calcineurin regulatory subunit family. CHP subfamily.
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