TIMM13 Antibody - #DF12773
| Product: | TIMM13 Antibody |
| Catalog: | DF12773 |
| Description: | Rabbit polyclonal antibody to TIMM13 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Chicken, Xenopus |
| Mol.Wt.: | 11 kDa; 11kD(Calculated). |
| Uniprot: | Q9Y5L4 |
| RRID: | AB_2845734 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12773, RRID:AB_2845734.
Fold/Unfold
Mitochondrial import inner membrane translocase subunit TIM13; Mitochondrial import inner membrane translocase subunit Tim13B; ppv1; TIM 13; TIM13; TIM13_HUMAN; TIM13B; TIMM 13; Timm13; TIMM13A; TIMM13B; Translocase of inner mitochondrial membrane 13 homolog;
Immunogens
- Q9Y5L4 TIM13_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEGGFGSDFGGSGSGKLDPGLIMEQVKVQIAVANAQELLQRMTDKCFRKCIGKPGGSLDNSEQKCIAMCMDRYMDAWNTVSRAYNSRLQRERANM
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y5L4 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| R72 | Methylation | Uniprot |
Research Backgrounds
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins.
Mitochondrion inner membrane>Peripheral membrane protein>Intermembrane side.
Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.
Heterohexamer; composed of 3 copies of TIMM8 (TIMM8A or TIMM8B) and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22.
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).
Belongs to the small Tim family.
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