ARL4C Antibody - #DF12833
| Product: | ARL4C Antibody |
| Catalog: | DF12833 |
| Description: | Rabbit polyclonal antibody to ARL4C |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 21 kDa; 21kD(Calculated). |
| Uniprot: | P56559 |
| RRID: | AB_2845794 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12833, RRID:AB_2845794.
Fold/Unfold
ADP ribosylation factor like 4C; ADP ribosylation factor like 7; ADP-ribosylation factor-like protein 4C; ADP-ribosylation factor-like protein 7; ADP-ribosylation factor-like protein LAK; Arl4c; ARL4C_HUMAN; ARL7; LAK;
Immunogens
Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta.
- P56559 ARL4C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGNISSNISAFQSLHIVMLGLDSAGKTTVLYRLKFNEFVNTVPTIGFNTEKIKLSNGTAKGISCHFWDVGGQEKLRPLWKSYSRCTDGIIYVVDSVDVDRLEEAKTELHKVTKFAENQGTPLLVIANKQDLPKSLPVAEIEKQLALHELIPATTYHVQPACAIIGEGLTEGMDKLYEMILKRRKSLKQKKKR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P56559 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K51 | Ubiquitination | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K74 | Ubiquitination | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| K133 | Ubiquitination | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| S185 | Phosphorylation | Uniprot |
Research Backgrounds
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.
Cell projection>Filopodium. Cell membrane. Cytoplasm.
Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta.
Interacts with CYTH2. Interacts with alpha tubulin; interaction is independent on the ARL4C GTP or GDP binding status.
Belongs to the small GTPase superfamily. Arf family.
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