ARMET Antibody - #DF12836
| Product: | ARMET Antibody |
| Catalog: | DF12836 |
| Description: | Rabbit polyclonal antibody to ARMET |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 15 kDa; 21kD(Calculated). |
| Uniprot: | P55145 |
| RRID: | AB_2845797 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12836, RRID:AB_2845797.
Fold/Unfold
Arginine rich mutated in early stage tumors; Arginine rich protein; Arginine-rich protein; ARMET; ARMET protein; ARP; Manf; MANF_HUMAN; Mesencephalic astrocyte derived neurotrophic factor; Mesencephalic astrocyte-derived neurotrophic factor; MGC142148; MGC142150; Protein ARMET;
Immunogens
- P55145 MANF_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRRMWATQGLAVALALSVLPGSRALRPGDCEVCISYLGRFYQDLKDRDVTFSPATIENELIKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYAPKAASARTDL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P55145 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T7 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| K45 | Ubiquitination | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| K94 | Acetylation | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| S114 | Phosphorylation | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| Y121 | Phosphorylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| K152 | Ubiquitination | Uniprot | |
| K174 | Ubiquitination | Uniprot |
Research Backgrounds
Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (By similarity). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions.
May contain sialic acid residues.
Secreted. Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen.
Note: Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475, PubMed:29497057).
Interacts with HSPA5; the interaction is direct. Component of a complex containing at least CRELD2, MANF, MATN3 and PDIA4 (By similarity).
The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response.
The N-terminal region may be required for lipid sulfatide binding.
Belongs to the ARMET family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.