BEX1/2 Antibody - #DF12853
| Product: | BEX1/2 Antibody |
| Catalog: | DF12853 |
| Description: | Rabbit polyclonal antibody to BEX1/2 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine |
| Mol.Wt.: | 15 kDa; 15kD(Calculated). |
| Uniprot: | Q9BXY8 |
| RRID: | AB_2845814 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12853, RRID:AB_2845814.
Immunogens
Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines.
- Q9BXY8 BEX2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESKEERALNNLIVENVNQENDEKDEKEQVANKGEPLALPLNVSEYCVPRGNRRRFRVRQPILQYRWDIMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BXY8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K98 | Ubiquitination | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| S107 | Phosphorylation | Uniprot |
Research Backgrounds
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.
Cytoplasm. Nucleus.
Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines.
Interacts with OMP (By similarity). Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2.
Belongs to the BEX family.
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