Chromogranin B Antibody - #DF12897

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Product: Chromogranin B Antibody
Catalog: DF12897
Description: Rabbit polyclonal antibody to Chromogranin B
Application: WB
Reactivity: Human, Mouse
Mol.Wt.: 100 kDa; 78kD(Calculated).
Uniprot: P05060
RRID: AB_2845858

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
Chromogranin B Antibody detects endogenous levels of total Chromogranin B.
RRID:
AB_2845858
Cite Format: Affinity Biosciences Cat# DF12897, RRID:AB_2845858.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CCB peptide; Cg B; CgB; Chgb; Chromogranin-B; ChromograninB; SCG1; SCG1_HUMAN; Secretogranin 1; Secretogranin B; Secretogranin I; SgI;

Immunogens

Immunogen:
Uniprot:

P05060(SCG1_HUMAN) >>Visit HPA database.

Gene(ID):
CHGB(1114)
Expression:
P05060 SCG1_HUMAN:

Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.

Sequence:
MQPTLLLSLLGAVGLAAVNSMPVDNRNHNEGMVTRCIIEVLSNALSKSSAPPITPECRQVLKTSRKDVKDKETTENENTKFEVRLLRDPADASEAHESSSRGEAGAPGEEDIQGPTKADTEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKSQREDEEEEEGENYQKGERGEDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSETHAAGHSQEKTHSREKSSQESGEETGSQENHPQESKGQPRSQEESEEGEEDATSEVDKRRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRASEEEPEYGEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQSEESWDEEDKRNYPSLELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMSDTREEKRFLGEGHHRVQENQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKENREEARFQDKQYSSHHTAEKRKRLGELFNPYYDPLQWKSSHFERRDNMNDNFLEGEEENELTLNEKNFFPEYNYDWWEKKPFSEDVNWGYEKRNLARVPKLDLKRQYDRVAQLDQLLHYRKKSAEFPDFYDSEEPVSTHQEAENEKDRADQTVLTEDEKKELENLAAMDLELQKIAEKFSQRG

PTMs - P05060 As Substrate

Site PTM Type Enzyme
S46 Phosphorylation
S93 Phosphorylation
K117 Acetylation
S130 Phosphorylation
S140 Phosphorylation
S149 Phosphorylation
Y173 Phosphorylation
S182 Phosphorylation
S183 Phosphorylation
S225 Phosphorylation
S259 Phosphorylation
S263 Phosphorylation
T271 Phosphorylation
S272 Phosphorylation
S301 Phosphorylation
S311 Phosphorylation
S317 Phosphorylation
Y332 Phosphorylation
S335 Phosphorylation
Y341 Phosphorylation
S367 Phosphorylation
S377 Phosphorylation
S380 Phosphorylation
S391 Phosphorylation
Y401 Phosphorylation
S405 Phosphorylation
Y429 Phosphorylation
S432 Phosphorylation
Y525 Phosphorylation
Y526 Phosphorylation
S577 Phosphorylation
K598 Acetylation
Y613 Phosphorylation
S617 Phosphorylation
Y624 Phosphorylation
S626 Phosphorylation

Research Backgrounds

Function:

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

PTMs:

Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).

O-glycosylated.

Subcellular Location:

Secreted.
Note: Neuroendocrine and endocrine secretory granules.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.

Family&Domains:

Belongs to the chromogranin/secretogranin protein family.

Restrictive clause

 

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For Research Use Only.
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