CRMP4 Antibody - #DF12916
| Product: | CRMP4 Antibody |
| Catalog: | DF12916 |
| Description: | Rabbit polyclonal antibody to CRMP4 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Horse, Rabbit, Dog |
| Mol.Wt.: | 62 kDa; 62kD(Calculated). |
| Uniprot: | Q14195 |
| RRID: | AB_2845877 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12916, RRID:AB_2845877.
Fold/Unfold
Collapsin response mediator protein 4; Collapsin response mediator protein 4 long; CRMP 4; CRMP-4; CRMP4; Dihydropyrimidinase like 3; Dihydropyrimidinase related protein 3; Dihydropyrimidinase-related protein 3; DPYL3_HUMAN; DPYSL3; DRP 3; DRP-3; DRP3; LCRMP; TUC4; ULIP 1; ULIP; ULIP-1; ULIP1; UNc 33 like phosphoprotein 1; Unc 33 like phosphoprotein; Unc-33-like phosphoprotein 1;
Immunogens
Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
- Q14195 DPYL3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIVSAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITSLS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14195 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| S2 | Phosphorylation | Uniprot | |
| T13 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| Y32 | Phosphorylation | Uniprot | |
| Y251 | Phosphorylation | Uniprot | |
| T253 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| S265 | Phosphorylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| S385 | Phosphorylation | Uniprot | |
| K398 | Acetylation | Uniprot | |
| S402 | Phosphorylation | Uniprot | |
| Y431 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot | |
| Y499 | Phosphorylation | Uniprot | |
| T507 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T508 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T509 | Phosphorylation | Q00535 (CDK5) , Q92630 (DYRK2) , P49841 (GSK3B) , P24941 (CDK2) | Uniprot |
| K511 | Ubiquitination | Uniprot | |
| T514 | Phosphorylation | Q92630 (DYRK2) , Q00535 (CDK5) , P49841 (GSK3B) | Uniprot |
| S518 | Phosphorylation | Q00535 (CDK5) , Q92630 (DYRK2) , P49841 (GSK3B) | Uniprot |
| S522 | Phosphorylation | Q92630 (DYRK2) , Q00535 (CDK5) | Uniprot |
| T524 | Phosphorylation | Uniprot | |
| S536 | Phosphorylation | Uniprot | |
| S539 | Phosphorylation | Uniprot | |
| S541 | Phosphorylation | Uniprot | |
| T543 | Phosphorylation | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| S564 | Phosphorylation | Uniprot | |
| T567 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot | |
| S570 | Phosphorylation | Uniprot |
Research Backgrounds
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
Cytoplasm. Cell projection>Growth cone.
Note: Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity). Interacts with FLNA.
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
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