EXOC6 Antibody - #DF12989

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Product: EXOC6 Antibody
Catalog: DF12989
Description: Rabbit polyclonal antibody to EXOC6
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 116 kDa, 100 kDa; 94kD(Calculated).
Uniprot: Q8TAG9
RRID: AB_2845950

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Zebrafish(91%), Bovine(91%), Horse(100%), Sheep(91%), Rabbit(92%), Dog(100%), Chicken(91%)
Clonality:
Polyclonal
Specificity:
EXOC6 Antibody detects endogenous levels of total EXOC6.
RRID:
AB_2845950
Cite Format: Affinity Biosciences Cat# DF12989, RRID:AB_2845950.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DKFZp761I2124; EXOC 6; EXOC6; EXOC6A; Exocyst complex component 6; Exocyst complex component Sec15A; FLJ1125; FLJ11251; MGC33397; SEC15; SEC15 like 1; SEC15 like protein 1; SEC15 like protein 3; SEC15A; SEC15L; SEC15L1; SEC15L3; Sec15p;

Immunogens

Immunogen:
Uniprot:

Q8TAG9(EXOC6_HUMAN) >>Visit HPA database.

Gene(ID):
EXOC6(54536)
Sequence:
MAENSESLGTVPEHERILQEIESTDTACVGPTLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTDTNRRFQDAGKEVIVHTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSAKRYYSALKTMEQLENVYFPWVSQYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQHQKTFSVSLQKQNKMKFGKNMYINRDRIPEERNETVLKHSLEEEDENEEEILTVQDLVDFSPVYRCLHIYSVLGDEETFENYYRKQRKKQARLVLQPQSNMHETVDGYRRYFTQIVGFFVVEDHILHVTQGLVTRAYTDELWNMALSKIIAVLRAHSSYCTDPDLVLELKNLTVIFADTLQGYGFPVNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPVVNEEEYKIVISKFPFQDPDLEKQSFPKKFPMSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIRKPHIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACMSACQHLSTSLMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWSTYLADYGQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDRDKQKLIETVVKQLRSLVNGMSQHM

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Dog
100
Rabbit
92
Bovine
91
Sheep
91
Zebrafish
91
Chicken
91
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8TAG9 As Substrate

Site PTM Type Enzyme
S7 Phosphorylation
C28 S-Nitrosylation
K91 Ubiquitination
K106 Ubiquitination
Y155 Phosphorylation
Y175 Phosphorylation
K193 Ubiquitination
S196 Phosphorylation
S198 Phosphorylation
K201 Ubiquitination
K213 Ubiquitination
K220 Methylation
K226 Ubiquitination
S231 Phosphorylation
K234 Ubiquitination
K242 Ubiquitination
T301 Phosphorylation
S446 Phosphorylation
K462 Ubiquitination
K472 Ubiquitination
S503 Phosphorylation
S505 Phosphorylation
K519 Ubiquitination
K591 Ubiquitination
K604 Ubiquitination
K608 Ubiquitination
K791 Ubiquitination
S801 Phosphorylation

Research Backgrounds

Function:

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).

Subcellular Location:

Cytoplasm. Cytoplasm>Perinuclear region. Cell projection>Growth cone. Midbody>Midbody ring.
Note: Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation. Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with CNTRL. Interacts with RAB11A in a GTP-dependent manner (By similarity).

Family&Domains:

Belongs to the SEC15 family.

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