FAM46C Antibody - #DF12999

(2)  
Product: FAM46C Antibody
Catalog: DF12999
Description: Rabbit polyclonal antibody to FAM46C
Application: WB IHC
Reactivity: Human, Mouse
Mol.Wt.: 45 kDa; 45kD(Calculated).
Uniprot: Q5VWP2
RRID: AB_2845960

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
FAM46C Antibody detects endogenous levels of total FAM46C.
RRID:
AB_2845960
Cite Format: Affinity Biosciences Cat# DF12999, RRID:AB_2845960.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FA46C_HUMAN; Fam46c; Family with sequence similarity 46 member C; Protein FAM46C;

Immunogens

Immunogen:
Uniprot:

Q5VWP2(TET5C_HUMAN) >>Visit HPA database.

Gene(ID):
FAM46C(54855)
Sequence:
MAEESSCTRDCMSFSVLNWDQVSRLHEVLTEVVPIHGRGNFPTLEITLKDIVQTVRSRLEEAGIKVHDVRLNGSAAGHVLVKDNGLGCKDLDLIFHVALPTEAEFQLVRDVVLCSLLNFLPEGVNKLKISPVTLKEAYVQKLVKVCTDTDRWSLISLSNKNGKNVELKFVDSIRRQFEFSVDSFQIILDSLLFFYDCSNNPISEHFHPTVIGESMYGDFEEAFDHLQNRLIATKNPEEIRGGGLLKYSNLLVRDFRPTDQEEIKTLERYMCSRFFIDFPDILEQQRKLETYLQNHFAEEERSKYDYLMILRRVVNESTVCLMGHERRQTLNLISLLALRVLAEQNIIPSATNVTCYYQPAPYVSDGNFSNYYVAHPPVTYSQPYPTWLPCN

PTMs - Q5VWP2 As Substrate

Site PTM Type Enzyme
K49 Ubiquitination
K65 Ubiquitination
S74 Phosphorylation
K126 Ubiquitination
K128 Ubiquitination
K135 Ubiquitination
K141 Ubiquitination
K144 Ubiquitination
K168 Ubiquitination
K234 Ubiquitination
K246 Ubiquitination
K264 Ubiquitination
K287 Ubiquitination
K303 Ubiquitination

Research Backgrounds

Function:

Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.

(Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.

Subcellular Location:

Nucleus. Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with BCCIP and PABPC1; the interaction has no effect on TENT5C poly(A) polymerase function.

Family&Domains:

Belongs to the TENT family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.