FAM92A1 Antibody - #DF13000
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13000, RRID:AB_2845961.
Fold/Unfold
Family with sequence similarity 92, member A1; FLJ38979; Hypothetical protein LOC137392; Protein FAM92A1; RGD1310681;
Immunogens
- A1XBS5 FA92A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMRRTLENRNAQTKQLQTAVSNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINAYAATETPHLKLGLMNFADEFAKLQDYRQAEVERLEAKVVEPLKTYGTIVKMKRDDLKATLTARNREAKQLTQLERTRQRNPSDRHVISQAETELQRAAMDASRTSRHLEETINNFERQKMKDIKTIFSEFITIEMLFHGKALEVYTAAYQNIQNIDEDEDLEVFRNSLYAPDYSSRLDIVRANSKSPLQRSLSAKCVSGTGQVSTCRLRKDQQAEDDEDDELDVTEEENFLK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - A1XBS5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K14 | Ubiquitination | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| Y58 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| Y226 | Phosphorylation | Uniprot | |
| Y230 | Phosphorylation | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| S243 | Phosphorylation | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| T282 | Phosphorylation | Uniprot |
Research Backgrounds
Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis. In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis.
Cytoplasm. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole. Cytoplasm>Cytoskeleton>Cilium basal body. Cell projection>Cilium.
Note: Weak punctate vesicular distribution throughout the cytoplasm (PubMed:27528616). Localizes at the distal end of mother centrioles (PubMed:27528616). Extensive colocalization with CBY1 at mother centrioles (PubMed:27528616).
Nucleus.
Homodimer (via BAR-like domain). Heterodimer with FAM92B (via BAR-like domains). Interacts (via BAR-like domain) with CBY1; this interaction is required for targeting FAM92A to centriole and cilium basal body.
The BAR-like domain displays limited similarity to other BAR domains.
Belongs to the FAM92 family.
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