HRSP12 Antibody - #DF13072
| Product: | HRSP12 Antibody |
| Catalog: | DF13072 |
| Description: | Rabbit polyclonal antibody to HRSP12 |
| Application: | WB IHC |
| Reactivity: | Human, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Dog, Chicken, Xenopus |
| Mol.Wt.: | 14.5 kDa; 14kD(Calculated). |
| Uniprot: | P52758 |
| RRID: | AB_2846033 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13072, RRID:AB_2846033.
Fold/Unfold
14.5 kDa translational inhibitor protein; 2-iminobutanoate/2-iminopropanoate deaminase; Heat responsive protein 12; Heat-responsive protein 12; Hrsp12; p14.5; Perchloric acid soluble protein; PSP; Reactive intermediate imine deaminase A homolog; Ribonuclease UK114; RIDA; Translational inhibitor p14.5; Translational inhibitor protein p14.5; UK114; UK114 antigen homolog; UK114_HUMAN;
Immunogens
- P52758 RIDA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSGQLVSGGVAEEAKQALKNMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKSNFPARAAYQVAALPKGSRIEIEAVAIQGPLTTASL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P52758 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| Y21 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| T74 | Phosphorylation | Uniprot | |
| T91 | Phosphorylation | Uniprot | |
| K101 | Acetylation | Uniprot | |
| Y110 | Phosphorylation | Uniprot | |
| S136 | Phosphorylation | Uniprot |
Research Backgrounds
Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.
Cytoplasm. Nucleus. Peroxisome. Mitochondrion.
Note: Mostly cytoplasmic but, in less differentiated cells occasionally nuclear.
Expressed predominantly in liver and kidney. Lower levels in lung and brain.
Homotrimer. Interacts with YTHDF2.
Belongs to the RutC family.
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