KCTD5 Antibody - #DF13105
| Product: | KCTD5 Antibody |
| Catalog: | DF13105 |
| Description: | Rabbit polyclonal antibody to KCTD5 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Sheep, Rabbit, Dog |
| Mol.Wt.: | 26 kDa; 26kD(Calculated). |
| Uniprot: | Q9NXV2 |
| RRID: | AB_2846065 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13105, RRID:AB_2846065.
Fold/Unfold
BTB/POZ domain-containing protein KCTD5; FLJ20040; KCTD5; KCTD5_HUMAN; Potassium channel tetramerisation domain containing 5;
Immunogens
- Q9NXV2 KCTD5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQVPVKHVYRVLQCQEEELTQMVSTMSDGWKFEQLVSIGSSYNYGNEDQAEFLCVVSKELHNTPYGTASEPSEKAKILQERGSRM
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NXV2 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| R13 | Methylation | Uniprot | |
| R26 | Methylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| Y191 | Phosphorylation | Uniprot | |
| Y193 | Phosphorylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| K225 | Ubiquitination | Uniprot |
Research Backgrounds
Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.
Cytoplasm>Cytosol. Cytoplasm. Nucleus.
Note: Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins.
Homopentamer. Interacts (via C-terminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins. Interacts with CRY1 (By similarity).
(Microbial infection) Interacts with adeno-associated virus 2 (AAV-2) REP proteins.
The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer (PubMed:19361449). Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118.
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