LZTFL1 Antibody - #DF13134
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13134, RRID:AB_2846094.
Fold/Unfold
5530402H04Rik; 6130400H19Rik; AI414725; AW048545; BBS17; DKFZp686H2076; FLJ36386; Leucine zipper transcription factor like 1; Leucine zipper transcription factor like protein 1; Leucine zipper transcription factor-like protein 1; LZTFL 1; Lztfl1; Lztfl1 leucine zipper transcription factor-like 1; LZTL1_HUMAN; MGC106871; MGC108960; Putative uncharacterized protein DKFZp686H2076;
Immunogens
Expressed in prostate, ovary, stomach, pancreas, esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at protein level). Down-regulated in multiple primary tumors (at protein level). Detected in testis, heart, skeletal muscle, thymus, spleen, small intestine, and peripheral blood leukocytes.
- Q9NQ48 LZTL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKESRLVEDTFTIDEVSEVLNGLQAVVHSEVESELINTAYTNVLLLRQLFAQAEKWYLKLQTDISELENRELLEQVAEFEKAEITSSNKKPILDVTKPKLAPLNEGGTAELLNKEILRLQEENEKLKSRLKTIEIQATNALDEKSKLEKALQDLQLDQGNQKDFIKAQDLSNLENTVAALKSEFQKTLNDKTENQKSLEENLATAKHDLLRVQEQLHMAEKELEKKFQQTAAYRNMKEILTKKNDQIKDLRKRLAQYEPED
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NQ48 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K30 | Ubiquitination | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| K152 | Ubiquitination | Uniprot | |
| R156 | Methylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| T176 | Phosphorylation | Uniprot | |
| S209 | Phosphorylation | Uniprot | |
| K219 | Ubiquitination | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| K244 | Ubiquitination | Uniprot |
Research Backgrounds
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Cytoplasm.
Expressed in prostate, ovary, stomach, pancreas, esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at protein level). Down-regulated in multiple primary tumors (at protein level). Detected in testis, heart, skeletal muscle, thymus, spleen, small intestine, and peripheral blood leukocytes.
Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.
Belongs to the LZTFL1 family.
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