MACC1 Antibody - #DF13135
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13135, RRID:AB_2846095.
Fold/Unfold
7A5; MACC1; MACC1_HUMAN; Metastasis associated in colon cancer 1; Metastasis-associated in colon cancer protein 1; OTTHUMP00000201891; Putative binding protein 7a5; SH3 domain-containing protein 7a5; SH3BP4L;
Immunogens
- Q6ZN28 MACC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLITERKHFRSGRIAQSMSEANLIDMEAGKLSKSCNITECQDPDLLHNWPDAFTLRGNNASKVANPFWNQLSASNPFLDDITQLRNNRKRNNISILKEDPFLFCREIENGNSFDSSGDELDVHQLLRQTSSRNSGRSKSVSELLDILDDTAHAHQSIHNSDQILLHDLEWLKNDREAYKMAWLSQRQLARSCLDLNTISQSPGWAQTQLAEVTIACKVNHQGGSVQLPESDITVHVPQGHVAVGEFQEVSLRAFLDPPHMLNHDLSCTVSPLLEIMLGNLNTMEALLLEMKIGAEVRKDPFSQVMTEMVCLHSLGKEGPFKVLSNCYIYKDTIQVKLIDLSQVMYLVVAAQAKALPSPAATIWDYIHKTTSIGIYGPKYIHPSFTVVLTVCGHNYMPGQLTISDIKKGGKNISPVVFQLWGKQSFLLDKPQDLSISIFSCDPDFEVKTEGERKEIKQKQLEAGEVVHQQFLFSLVEHREMHLFDFCVQVEPPNGEPVAQFSITTPDPTPNLKRLSNLPGYLQKKEEIKSAPLSPKILVKYPTFQDKTLNFSNYGVTLKAVLRQSKIDYFLEYFKGDTIALLGEGKVKAIGQSKVKEWYVGVLRGKIGLVHCKNVKVISKEQVMFMSDSVFTTRNLLEQIVLPLKKLTYIYSVVLTLVSEKVYDWKVLADVLGYSHLSLEDFDQIQADKESEKVSYVIKKLKEDCHTERNTRKFLYELIVALLKMDCQELVARLIQEAAVLTSAVKLGKGWRELAEKLVRLTKQQMEAYEIPHRGNTGDVAVEMMWKPAYDFLYTWSAHYGNNYRDVLQDLQSALDRMKNPVTKHWRELTGVLILVNSLEVLRVTAFSTSEEV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6ZN28 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T4 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S112 | Phosphorylation | Uniprot | |
| S115 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| Y178 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| S413 | Phosphorylation | Uniprot | |
| S515 | Phosphorylation | Uniprot | |
| S533 | Phosphorylation | Uniprot | |
| Y568 | Phosphorylation | Uniprot | |
| Y572 | Phosphorylation | Uniprot | |
| K645 | Acetylation | Uniprot | |
| Y650 | Phosphorylation | Uniprot | |
| Y803 | Phosphorylation | Uniprot |
Research Backgrounds
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
Cytoplasm. Nucleus.
Note: Mainly found in the cytoplasm in non-metastasizing tumors.
Preferentially expressed in metastasizing tumors.
Interacts with FASLG.
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