MICAL2 Antibody - #DF13149
| Product: | MICAL2 Antibody |
| Catalog: | DF13149 |
| Description: | Rabbit polyclonal antibody to MICAL2 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Horse, Sheep, Rabbit |
| Mol.Wt.: | 112 kDa; 127kD(Calculated). |
| Uniprot: | O94851 |
| RRID: | AB_2846109 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13149, RRID:AB_2846109.
Fold/Unfold
flavoprotein oxidoreductase MICAL2; KIAA0750; MICAL2PV1; MICAL2PV2; microtubule associated monoxygenase, calponin and LIM domain containing 2; Molecule interacting with CasL protein 2; Protein-methionine sulfoxide oxidase MICAL2;
Immunogens
- O94851 MICA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMANQLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQFPSVVVTGHVLRELKQVSAGSECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVLWRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKLLSKGLSHTHPPSPPSRLPSPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEATWQEQEAPRRDTPTESSCAVAAIGTLEGSPPVHFSLPVLHPLLG
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O94851 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K68 | Methylation | Uniprot | |
| T228 | Phosphorylation | Uniprot | |
| K458 | Ubiquitination | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| S511 | Phosphorylation | Uniprot | |
| S515 | Phosphorylation | Uniprot | |
| K597 | Acetylation | Uniprot | |
| S631 | Phosphorylation | Uniprot | |
| K634 | Ubiquitination | Uniprot | |
| K646 | Ubiquitination | Uniprot | |
| S648 | Phosphorylation | Uniprot | |
| Y653 | Phosphorylation | Uniprot | |
| T657 | Phosphorylation | Uniprot | |
| S696 | Phosphorylation | Uniprot | |
| S813 | Phosphorylation | Uniprot | |
| T820 | Phosphorylation | Uniprot | |
| S828 | Phosphorylation | Uniprot | |
| T829 | Phosphorylation | Uniprot | |
| S908 | Phosphorylation | Uniprot | |
| S916 | Phosphorylation | Uniprot | |
| T919 | Phosphorylation | Uniprot | |
| S991 | Phosphorylation | Uniprot |
Research Backgrounds
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Nucleus.
Interacts with PLXNA4 (By similarity). Interacts with RAB1B.
Belongs to the Mical family.
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