MYEOV Antibody - #DF13163
| Product: | MYEOV Antibody |
| Catalog: | DF13163 |
| Description: | Rabbit polyclonal antibody to MYEOV |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Sheep, Chicken, Xenopus |
| Mol.Wt.: | 55 kDa; 6kD(Calculated). |
| Uniprot: | Q8WXC6 |
| RRID: | AB_2846123 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13163, RRID:AB_2846123.
Fold/Unfold
Helicase/primase complex protein; Myeloma overexpressed 2; Myeloma-overexpressed gene 2 protein; myeov2; MYOV2_HUMAN;
Immunogens
- Q8WXC6 CSN9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKPAVDEMFPEGAGPYVDLDEAGGSTGLLMDLAANEKAVHADFFNDFEDLFDDDDIQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8WXC6 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T26 | Phosphorylation | Uniprot |
Research Backgrounds
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.
Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.
Nucleus. Cytoplasm. Nucleus>Nucleoplasm.
Note: Excluded from the nucleolus. Recruited to the nucleoplasm and chromatin following DNA damage induction.
Nucleus>Nucleoplasm.
Note: Excluded from the nucleolus.
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1. In the complex, it interacts directly with COPS3, COPS5 and COPS6. Isoform 2 associates with CSN complex. Isoform 2 interacts with COPS5, CUL1, CUL3 and RPL11. According to does not associate with CSN complex.
The Phe/Asp-rich domain at the C-terminus is necessary for its incorporation into the CSN complex.
Amino acids 60-89 in isoform 2 are necessary for interaction with COPS5, CUL1, CUL3.
Belongs to the CSN9 family.
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