OSBPL10 Antibody - #DF13209

(3)  
Product: OSBPL10 Antibody
Catalog: DF13209
Description: Rabbit polyclonal antibody to OSBPL10
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Horse, Rabbit, Dog
Mol.Wt.: 80 kDa; 84kD(Calculated).
Uniprot: Q9BXB5
RRID: AB_2846169

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(80%), Horse(90%), Rabbit(90%), Dog(90%)
Clonality:
Polyclonal
Specificity:
OSBPL10 Antibody detects endogenous levels of total OSBPL10.
RRID:
AB_2846169
Cite Format: Affinity Biosciences Cat# DF13209, RRID:AB_2846169.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FLJ20363; ORP-10; ORP10; OSB10_HUMAN; OSBP related protein 10; OSBP-related protein 10; OSBP9; OSBPL 10; OSBPL10; Oxysterol binding protein like 10; Oxysterol binding protein related protein 10; Oxysterol-binding protein-related protein 10;

Immunogens

Immunogen:
Uniprot:

Q9BXB5(OSB10_HUMAN) >>Visit HPA database.

Gene(ID):
OSBPL10(114884)
Sequence:
MERAVQGTDGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYHMEMNSKSAPSSRSRSLTLLPHGTPNSASPCSQRHLSVGAPGVVTITHHKSPAAARRAKSQYSGQLHEVREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLNLLQQSVHQAGQPSQKPGASENILGWHGSKSHSTEQLKNGTLGSLPSASANITWAILPNSAEDEQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWKAH

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
90
Dog
90
Rabbit
90
Pig
80
Bovine
0
Sheep
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9BXB5 As Substrate

Site PTM Type Enzyme
T8 Phosphorylation
S16 Phosphorylation
S17 Phosphorylation
S20 Phosphorylation
S21 Phosphorylation
S26 Phosphorylation
S29 Phosphorylation
S30 Phosphorylation
S32 Phosphorylation
R38 Methylation
S44 Phosphorylation
S54 Phosphorylation
S56 Phosphorylation
S57 Phosphorylation
S60 Phosphorylation
S64 Phosphorylation
S66 Phosphorylation
K159 Ubiquitination
S188 Phosphorylation
T196 Phosphorylation
S199 Phosphorylation
S201 Phosphorylation
S204 Phosphorylation
S209 Phosphorylation
T217 Phosphorylation
S223 Phosphorylation
K231 Methylation
K231 Ubiquitination
S232 Phosphorylation
Y234 Phosphorylation
S235 Phosphorylation
S265 Phosphorylation
S322 Phosphorylation
S326 Phosphorylation
S375 Phosphorylation
S380 Phosphorylation
T388 Phosphorylation
K425 Acetylation
K425 Ubiquitination
Y479 Phosphorylation
S507 Phosphorylation
S510 Phosphorylation
S561 Phosphorylation
K685 Ubiquitination
K721 Ubiquitination
K762 Ubiquitination

Research Backgrounds

Function:

Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable). Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine.

Subcellular Location:

Cytoplasm>Cytoskeleton.
Note: Associates with microtubules.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with OSBPL9. Interacts with DIAPH1.

Family&Domains:

The C-terminal region binds cholesterol, 25-hydroxysterol and acidic phospholipids and is required for localization to microtubules.

The PH domain selectively interacts with phosphatidylinositol-4-phosphate.

Belongs to the OSBP family.

Restrictive clause

 

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