SNTB2 Antibody - #DF13272
Product: | SNTB2 Antibody |
Catalog: | DF13272 |
Description: | Rabbit polyclonal antibody to SNTB2 |
Application: | WB IHC IF/ICC |
Reactivity: | Human, Mouse, Rat |
Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
Mol.Wt.: | 57kDa; 58kD(Calculated). |
Uniprot: | Q13425 |
RRID: | AB_2846291 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13272, RRID:AB_2846291.
Fold/Unfold
;Syntrophin like; 59 kDa dystrophin associated protein A1 basic component 2; 59 kDa dystrophin-associated protein A1 basic component 2; Basic beta 2 syntrophin; Beta 2 syntrophin; Beta-2-syntrophin; D16S2531E; Dystrophin associated protein A1 59kD basic component 2; EST25263; SNT2B2; SNT3; Sntb2; SNTB2_HUMAN; SNTL; Syntrophin 3; Syntrophin beta 2 (dystrophin associated protein A1 59kDa basic component 2); Syntrophin-3; Syntrophin-like;
Immunogens
A synthesized peptide derived from human SNTB2, corresponding to a region within the internal amino acids.
Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.
- Q13425 SNTB2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRVAAATAAAGAGPAMAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELEPALGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNSTKDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGIEMHLFRVETHRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYENGFTISRENGGSSSILYRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKVTRMGLLV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
Research Backgrounds
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.
Phosphorylated. Partially dephosphorylated upon insulin stimulation.
Membrane. Cytoplasmic vesicle>Secretory vesicle membrane>Peripheral membrane protein. Cell junction. Cytoplasm>Cytoskeleton.
Note: Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules.
Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.
The PH 1 domain mediates the oligomerization in a calcium dependent manner.
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).
The SU domain binds calmodulin in a calcium-dependent manner.
Belongs to the syntrophin family.
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