RBPMS Antibody - #DF13276
| Product: | RBPMS Antibody |
| Catalog: | DF13276 |
| Description: | Rabbit polyclonal antibody to RBPMS |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Zebrafish, Chicken |
| Mol.Wt.: | 21kDa,24kDa; 22kD(Calculated). |
| Uniprot: | Q93062 |
| RRID: | AB_2846295 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13276, RRID:AB_2846295.
Fold/Unfold
FLJ32971; Heart and RRM expressed sequence; Hermes; RBP MS; RBP-MS; Rbpms; RBPMS_HUMAN; RNA binding protein gene with multiple splicing; RNA-binding protein with multiple splicing;
Immunogens
Ubiquitously expressed, at various levels depending on the isoform and the tissue.
- Q93062 RBPMS_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNNGGKAEKENTPSEANLQEEEVRTLFVSGLPLDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKANTKMAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAPALPPPAFTYPASLHAQMRWLPPSEATSQGWKSRQFC
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q93062 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K9 | Ubiquitination | Uniprot | |
| T12 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| T25 | Phosphorylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| T113 | Phosphorylation | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| T118 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| S144 | Phosphorylation | Uniprot |
Research Backgrounds
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.
Nucleus. Cytoplasm. Cytoplasm>P-body.
Note: Translocates into cytoplasmic stress granules that probably correspond to P-bodies in response to oxidative stress.
Ubiquitously expressed, at various levels depending on the isoform and the tissue.
Homodimer; each protein chain binds one RNA molecule via the external surface of the homodimer. Interacts with SMAD2, SMAD3 and SMAD4; the interactions are direct.
The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity.
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