ITIH2 Antibody - #DF13454
| Product: | ITIH2 Antibody |
| Catalog: | DF13454 |
| Description: | Rabbit polyclonal antibody to ITIH2 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 106kDa; 106kD(Calculated). |
| Uniprot: | P19823 |
| RRID: | AB_2846473 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13454, RRID:AB_2846473.
Fold/Unfold
AI747202; H2P; IGHEP2; Inter alpha (globulin) inhibitor H2; Inter alpha globulin inhibitor H2 polypeptide; Inter alpha trypsin inhibitor complex component II; Inter alpha trypsin inhibitor heavy chain H2; Inter-alpha-inhibitor heavy chain 2; Inter-alpha-trypsin inhibitor complex component II; Inter-alpha-trypsin inhibitor heavy chain H2; Intin2; ITI HC2; ITI heavy chain H2; ITI-HC2; Itih 2; Itih2; ITIH2_HUMAN; OTTHUMP00000019058; OTTHUMP00000019059; OTTMUSP00000012019; RP23 119N4.3; Serum derived hyaluronan associated protein; Serum-derived hyaluronan-associated protein; SHAP;
Immunogens
- P19823 ITIH2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKRLTCFFICFFLSEVSGFEIPINGLSEFVDYEDLVELAPGKFQLVAENRRYQRSLPGESEEMMEEVDQVTLYSYKVQSTITSRMATTMIQSKVVNNSPQPQNVVFDVQIPKGAFISNFSMTVDGKTFRSSIKEKTVGRALYAQARAKGKTAGLVRSSALDMENFRTEVNVLPGAKVQFELHYQEVKWRKLGSYEHRIYLQPGRLAKHLEVDVWVIEPQGLRFLHVPDTFEGHFDGVPVISKGQQKAHVSFKPTVAQQRICPNCRETAVDGELVVLYDVKREEKAGELEVFNGYFVHFFAPDNLDPIPKNILFVIDVSGSMWGVKMKQTVEAMKTILDDLRAEDHFSVIDFNQNIRTWRNDLISATKTQVADAKRYIEKIQPSGGTNINEALLRAIFILNEANNLGLLDPNSVSLIILVSDGDPTVGELKLSKIQKNVKENIQDNISLFSLGMGFDVDYDFLKRLSNENHGIAQRIYGNQDTSSQLKKFYNQVSTPLLRNVQFNYPHTSVTDVTQNNFHNYFGGSEIVVAGKFDPAKLDQIESVITATSANTQLVLETLAQMDDLQDFLSKDKHADPDFTRKLWAYLTINQLLAERSLAPTAAAKRRITRSILQMSLDHHIVTPLTSLVIENEAGDERMLADAPPQDPSCCSGALYYGSKVVPDSTPSWANPSPTPVISMLAQGSQVLESTPPPHVMRVENDPHFIIYLPKSQKNICFNIDSEPGKILNLVSDPESGIVVNGQLVGAKKPNNGKLSTYFGKLGFYFQSEDIKIEISTETITLSHGSSTFSLSWSDTAQVTNQRVQISVKKEKVVTITLDKEMSFSVLLHRVWKKHPVNVDFLGIYIPPTNKFSPKAHGLIGQFMQEPKIHIFNERPGKDPEKPEASMEVKGQKLIITRGLQKDYRTDLVFGTDVTCWFVHNSGKGFIDGHYKDYFVPQLYSFLKRP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P19823 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S55 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| T267 | Phosphorylation | Uniprot | |
| Y277 | Phosphorylation | Uniprot | |
| N445 | N-Glycosylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| S597 | Phosphorylation | Uniprot | |
| T601 | O-Glycosylation | Uniprot | |
| T601 | Phosphorylation | Uniprot | |
| S783 | Phosphorylation | Uniprot | |
| T817 | Phosphorylation | Uniprot | |
| S886 | Phosphorylation | Uniprot |
Research Backgrounds
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Phosphorylated by FAM20C in the extracellular medium.
Secreted.
Plasma.
I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.
Belongs to the ITIH family.
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