LAP1 Antibody - #DF13511
| Product: | LAP1 Antibody |
| Catalog: | DF13511 |
| Description: | Rabbit polyclonal antibody to LAP1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Zebrafish, Bovine, Horse, Sheep, Chicken |
| Mol.Wt.: | 50~70kD,172kD; 173kD(Calculated). |
| Uniprot: | Q96NW7 |
| RRID: | AB_2846530 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13511, RRID:AB_2846530.
Fold/Unfold
Densin 180; Densin; Densin-180; densin180; DKFZp686I1147; KIAA1365; Lamin associated polypeptide 1; LAP 1; Leucine rich repeat containing 7; Leucine rich repeat containing protein 7; Leucine-rich repeat-containing protein 7; Lrrc 7; LRRC7; LRRC7_HUMAN; MGC144918; OTTHUMP00000065336; OTTHUMP00000065337; OTTHUMP00000065338; Protein Lap 1; Protein lap1;
Immunogens
- Q96NW7 LRRC7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNSLWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFVAEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSNPNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKVYNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQKASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYPPMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPTDRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDHQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96NW7 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y52 | Phosphorylation | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| Y234 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| T348 | Phosphorylation | Uniprot | |
| S351 | Phosphorylation | Uniprot | |
| K381 | Ubiquitination | Uniprot | |
| T411 | Phosphorylation | Uniprot | |
| T570 | Phosphorylation | Uniprot | |
| Y572 | Phosphorylation | Uniprot | |
| T602 | Phosphorylation | Uniprot | |
| K612 | Acetylation | Uniprot | |
| S708 | Phosphorylation | Uniprot | |
| T711 | Phosphorylation | Uniprot | |
| T856 | Phosphorylation | Uniprot | |
| S1012 | Phosphorylation | Uniprot | |
| S1013 | Phosphorylation | Uniprot | |
| S1156 | Phosphorylation | Uniprot | |
| T1161 | Phosphorylation | Uniprot | |
| S1163 | Phosphorylation | Uniprot | |
| K1167 | Methylation | Uniprot | |
| Y1179 | Phosphorylation | Uniprot | |
| T1215 | Phosphorylation | Uniprot | |
| T1368 | Phosphorylation | Uniprot | |
| T1370 | Phosphorylation | Uniprot | |
| S1383 | Phosphorylation | Uniprot | |
| S1439 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| S1491 | Phosphorylation | Uniprot |
Research Backgrounds
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
Cytoplasm. Cell junction>Synapse>Postsynaptic density.
Brain-specific. Isoform 3 is ubiquitously expressed.
Interacts with CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2. Interacts with CAMK2A.
Belongs to the LAP (LRR and PDZ) protein family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.