SLFN11 Antibody - #DF13515
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13515, RRID:AB_2846534.
Fold/Unfold
Schlafen family member 11; SLFN11; SLFN8/9; SLN11_HUMAN;
Immunogens
Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.
- Q7Z7L1 SLN11_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEANQCPLVVEPSYPDLVINVGEVTLGEENRKKLQKIQRDQEKERVMRAACALLNSGGGVIRMAKKVEHPVEMGLDLEQSLRELIQSSDLQAFFETKQQGRCFYIFVKSWSSGPFPEDRSVKPRLCSLSSSLYRRSETSVRSMDSREAFCFLKTKRKPKILEEGPFHKIHKGVYQELPNSDPADPNSDPADLIFQKDYLEYGEILPFPESQLVEFKQFSTKHFQEYVKRTIPEYVPAFANTGGGYLFIGVDDKSREVLGCAKENVDPDSLRRKIEQAIYKLPCVHFCQPQRPITFTLKIVNVLKRGELYGYACMIRVNPFCCAVFSEAPNSWIVEDKYVCSLTTEKWVGMMTDTDPDLLQLSEDFECQLSLSSGPPLSRPVYSKKGLEHKKELQQLLFSVPPGYLRYTPESLWRDLISEHRGLEELINKQMQPFFRGILIFSRSWAVDLNLQEKPGVICDALLIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKVCVRAKVLCLSPESSAEALEAAVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLSDQLGCEVLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHCEAHRILYVCENQPLRNFISDRNICRAETRKTFLRENFEHIQHIVIDEAQNFRTEDGDWYGKAKSITRRAKGGPGILWIFLDYFQTSHLDCSGLPPLSDQYPREELTRIVRNADPIAKYLQKEMQVIRSNPSFNIPTGCLEVFPEAEWSQGVQGTLRIKKYLTVEQIMTCVADTCRRFFDRGYSPKDVAVLVSTAKEVEHYKYELLKAMRKKRVVQLSDACDMLGDHIVLDSVRRFSGLERSIVFGIHPRTADPAILPNVLICLASRAKQHLYIFPWGGH
PTMs - Q7Z7L1 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S56 | Phosphorylation | Uniprot | |
| K66 | Ubiquitination | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| K153 | Acetylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| T220 | Phosphorylation | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| K385 | Acetylation | Uniprot | |
| K391 | Acetylation | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| K495 | Ubiquitination | Uniprot | |
| K497 | Ubiquitination | Uniprot | |
| K507 | Ubiquitination | Uniprot | |
| K605 | Ubiquitination | Uniprot | |
| Y681 | Phosphorylation | Uniprot | |
| K683 | Acetylation | Uniprot | |
| K683 | Ubiquitination | Uniprot | |
| K739 | Ubiquitination | Uniprot | |
| K743 | Ubiquitination | Uniprot | |
| K807 | Ubiquitination | Uniprot | |
| K817 | Ubiquitination | Uniprot | |
| K823 | Ubiquitination | Uniprot | |
| K828 | Ubiquitination | Uniprot | |
| S863 | Phosphorylation | Uniprot | |
| T872 | Phosphorylation | Uniprot | |
| S887 | Phosphorylation | Uniprot | |
| K890 | Ubiquitination | Uniprot |
Research Backgrounds
Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Acts independently of ATR. Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA.
Nucleus. Chromosome.
Note: Recruited to stressed replication forks carrying extended RPA filaments (PubMed:29395061). Recruited to DNA damage sites via interaction with RPA1 (PubMed:26658330, PubMed:29395061).
Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.
Interacts with MCM3. Interacts with DHX9. Interacts with RPA1.
Belongs to the Schlafen family. Subgroup III subfamily.
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