ESE1 Antibody - #DF13530
| Product: | ESE1 Antibody |
| Catalog: | DF13530 |
| Description: | Rabbit polyclonal antibody to ESE1 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 42kDa,55kDa; 41kD(Calculated). |
| Uniprot: | P78545 |
| RRID: | AB_2846549 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13530, RRID:AB_2846549.
Fold/Unfold
E74 like factor 3; E74 like factor 3 ets domain transcription factor; E74 like factor 3 ets domain transcription factor epithelial specific; E74 like factor 3 ETS domain transcription factor serine box epithelial specific; E74-like factor 3; Elf3; ELF3_HUMAN; Epithelial restricted with serine box; Epithelial-restricted with serine box; Epithelium restricted Ets protein ESX; Epithelium specific Ets factor 1; Epithelium specific Ets transcription factor 1; Epithelium-restricted Ets protein ESX; Epithelium-specific Ets transcription factor 1; EPR 1; EPR1; ERT; ESE-1; ESX; Ets domain transcription factor serine box; Ets domain transcription factor serine box epithelial specific; Ets transcription factor; ETS-related transcription factor Elf-3; jen; MGC139318;
Immunogens
Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
- P78545 ELF3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAATCEISNIFSNYFSAMYSSEDSTLASVPPAATFGADDLVLTLSNPQMSLEGTEKASWLGEQPQFWSKTQVLDWISYQVEKNKYDASAIDFSRCDMDGATLCNCALEELRLVFGPLGDQLHAQLRDLTSSSSDELSWIIELLEKDGMAFQEALDPGPFDQGSPFAQELLDDGQQASPYHPGSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVDLDPTDGKLFPSDGFRDCKKGDPKHGKRKRGRPRKLSKEYWDCLEGKKSKHAPRGTHLWEFIRDILIHPELNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNSSGWKEEEVLQSRN
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P78545 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S58 | Phosphorylation | Uniprot | |
| S68 | Phosphorylation | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| S207 | Phosphorylation | Q13153 (PAK1) | Uniprot |
| S212 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| S254 | Phosphorylation | Uniprot | |
| K264 | Ubiquitination | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| K304 | Acetylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| K318 | Methylation | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| K319 | Methylation | Uniprot | |
| K320 | Methylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| T325 | Phosphorylation | Uniprot | |
| Y326 | Phosphorylation | Uniprot | |
| K328 | Ubiquitination | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| K362 | Ubiquitination | Uniprot |
Research Backgrounds
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
Cytoplasm. Nucleus.
Note: Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.
Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3.
the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Belongs to the ETS family.
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