SNRP70 Antibody - #DF13550
| Product: | SNRP70 Antibody |
| Catalog: | DF13550 |
| Description: | Rabbit polyclonal antibody to SNRP70 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Zebrafish, Bovine, Sheep, Rabbit, Xenopus |
| Mol.Wt.: | 51kDa; 52kD(Calculated). |
| Uniprot: | P08621 |
| RRID: | AB_2846569 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13550, RRID:AB_2846569.
Fold/Unfold
RNPU1Z; Rnulp70; RPU1; Small nuclear ribonucleoprotein 70 (U1); Small nuclear ribonucleoprotein 70kD polypeptide (RNP antigen); Small nuclear ribonucleoprotein 70kDa (U1); Small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen); snRNP70; Snrp 70; SNRP70; U1 70K; U1 small nuclear ribonucleoprotein 70 kDa; U1 small nuclear ribonucleoprotein polypeptide A; U1 snRNP 70 kDa; U170K; U1AP; U1AP1; U1RNP;
Immunogens
A synthesized peptide derived from human SNRP70, corresponding to a region within the internal amino acids.
- P08621 RU17_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEARGGGGGQDNGLEGLGNDSRDMYMESEGGDGYLAPENGYLMEAAPE
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
Research Backgrounds
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA.
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
The N-terminus is blocked.
Extensively phosphorylated on serine residues in the C-terminal region.
Nucleus speckle. Nucleus>Nucleoplasm.
Note: Colocalizes with SCNM1 and LUC7L2 in nuclear speckles.
The RRM domain mediates interaction with U1 RNA.
Research Fields
· Genetic Information Processing > Transcription > Spliceosome.
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