Melanopsin Antibody - #DF13615

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Product: Melanopsin Antibody
Catalog: DF13615
Description: Rabbit polyclonal antibody to Melanopsin
Application: WB
Reactivity: Human, Mouse, Rat
Mol.Wt.: 52kDa; 53kD(Calculated).
Uniprot: Q9UHM6
RRID: AB_2846634

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
Melanopsin Antibody detects endogenous levels of total Melanopsin.
RRID:
AB_2846634
Cite Format: Affinity Biosciences Cat# DF13615, RRID:AB_2846634.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Immunogens

Immunogen:
Uniprot:

Q9UHM6(OPN4_HUMAN) >>Visit HPA database.

Gene(ID):
OPN4(94233)
Expression:
Q9UHM6 OPN4_HUMAN:

Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina.

Sequence:
MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGKTKGLIPSQDPRM

PTMs - Q9UHM6 As Substrate

Site PTM Type Enzyme
S379 Phosphorylation
S391 Phosphorylation
T392 Phosphorylation
T397 Phosphorylation
S398 Phosphorylation

Research Backgrounds

Function:

Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).

Subcellular Location:

Cell membrane>Multi-pass membrane protein.
Note: Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina.

Family&Domains:

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Restrictive clause

 

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