Mov10 Antibody - #DF13651

5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7. Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor. Exhibits antiviral activity against dengue virus (DENV).

(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

Cytoplasm>P-body. Cytoplasm>Cytoplasmic ribonucleoprotein granule. Cytoplasm>Stress granule. Nucleus. Cytoplasm.
Note: Co-enriched in cytoplasmic foci with TUT4 (PubMed:30122351). In developing neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (By similarity). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568).

Interacts with DICER1, AGO2, TARBP2, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with APOBEC3G in an RNA-dependent manner. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner. Interacts with both protein products of LIRE1, ORF1p and ORF2p. Interacts with TUT4 and, to a lesser extent, TUT7; the interactions are RNA-dependent. Interacts with AGO2, TNRC6B and UPF1; the interactions are direct and RNA-dependent. Interacts with FMR1; this interaction is direct, occurs in an RNA-dependent manner on polysomes and induces association of MOV10 with RNAs. Interacts with SHFL; the interaction increases in presence of RNA.

(Microbial infection) Interacts with the human hepatitis delta virus (HDV) antigen HDAg.

Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.