VLDL Receptor Antibody - #DF13667
| Product: | VLDL Receptor Antibody |
| Catalog: | DF13667 |
| Description: | Rabbit polyclonal antibody to VLDL Receptor |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus |
| Mol.Wt.: | 96kDa; 96kD(Calculated). |
| Uniprot: | P98155 |
| RRID: | AB_2846686 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13667, RRID:AB_2846686.
Fold/Unfold
FLJ35024; Very low density lipoprotein receptor; Very low-density lipoprotein receptor; VLDL R; VLDL receptor; VLDL-R; VLDLR; VLDLR_HUMAN; VLDLRCH;
Immunogens
- P98155 VLDLR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P98155 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T71 | O-Glycosylation | Uniprot | |
| T277 | O-Glycosylation | Uniprot | |
| Y524 | Phosphorylation | Uniprot | |
| S759 | Phosphorylation | Uniprot | |
| K828 | Ubiquitination | Uniprot | |
| Y837 | Phosphorylation | Uniprot | |
| K839 | Ubiquitination | Uniprot | |
| S846 | Phosphorylation | Uniprot | |
| Y860 | Phosphorylation | Uniprot | |
| S867 | Phosphorylation | Uniprot | |
| T868 | Phosphorylation | Uniprot |
Research Backgrounds
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).
Ubiquitinated at Lys-839 by MYLIP leading to degradation.
Membrane>Single-pass type I membrane protein. Membrane>Clathrin-coated pit>Single-pass type I membrane protein.
Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.
Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17 (By similarity). Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains. Interacts with PCSK9.
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