TACC2 Antibody - #DF13674

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Product: TACC2 Antibody
Catalog: DF13674
Description: Rabbit polyclonal antibody to TACC2
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Dog
Mol.Wt.: 309kDa; 309kD(Calculated).
Uniprot: O95359
RRID: AB_2846693

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Dog(83%)
Clonality:
Polyclonal
Specificity:
TACC2 Antibody detects endogenous levels of total TACC2.
RRID:
AB_2846693
Cite Format: Affinity Biosciences Cat# DF13674, RRID:AB_2846693.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Immunogens

Immunogen:
Uniprot:

O95359(TACC2_HUMAN) >>Visit HPA database.

Gene(ID):
TACC2(10579)
Expression:
O95359 TACC2_HUMAN:

Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea.

Sequence:
MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Dog
83
Sheep
67
Pig
0
Horse
0
Bovine
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O95359 As Substrate

Site PTM Type Enzyme
S8 Phosphorylation
T13 Phosphorylation
S15 Phosphorylation
T18 Phosphorylation
S41 Phosphorylation
S97 Phosphorylation
S161 Phosphorylation
Y164 Phosphorylation
S197 Phosphorylation
S201 Phosphorylation
S245 Phosphorylation
T249 Phosphorylation
S269 Phosphorylation
T411 Phosphorylation
S473 Phosphorylation
S493 Phosphorylation
S561 Phosphorylation
S569 Phosphorylation
S571 Phosphorylation
S575 Phosphorylation
S712 Phosphorylation
S749 Phosphorylation
S758 Phosphorylation
S859 Phosphorylation
S962 Phosphorylation
T983 Phosphorylation
T986 Phosphorylation
S993 Phosphorylation
S1005 Phosphorylation
S1025 Phosphorylation
T1235 Phosphorylation
Y1237 Phosphorylation
S1242 Phosphorylation
S1267 Phosphorylation
S1283 Phosphorylation
S1311 Phosphorylation
S1313 Phosphorylation
K1339 Methylation
K1346 Methylation
T1426 Phosphorylation
S1562 Phosphorylation
S1608 Phosphorylation
S1635 Phosphorylation
T1761 Phosphorylation
S1768 Phosphorylation
S1796 Phosphorylation
S1946 Phosphorylation
S1947 Phosphorylation
S1949 Phosphorylation
S2072 Phosphorylation
T2073 Phosphorylation
S2075 Phosphorylation
S2088 Phosphorylation
S2092 Phosphorylation
S2122 Phosphorylation
S2134 Phosphorylation
T2147 Phosphorylation
C2203 S-Nitrosylation
S2218 Phosphorylation
S2226 Phosphorylation
T2246 Phosphorylation
S2248 Phosphorylation
S2250 Phosphorylation
S2256 Phosphorylation
S2262 Phosphorylation
S2270 Phosphorylation
T2307 Phosphorylation
T2314 Phosphorylation
S2317 Phosphorylation
S2321 Phosphorylation
S2359 Phosphorylation
T2373 Phosphorylation
S2377 Phosphorylation
S2389 Phosphorylation
S2390 Phosphorylation
S2392 Phosphorylation
S2394 Phosphorylation
S2397 Phosphorylation
S2403 Phosphorylation
T2428 Phosphorylation
T2430 Phosphorylation
S2440 Phosphorylation
S2443 Phosphorylation
S2447 Phosphorylation
T2451 Phosphorylation
T2455 Phosphorylation
T2458 Phosphorylation
T2469 Phosphorylation
S2512 Phosphorylation
Y2519 Phosphorylation
S2522 Phosphorylation
S2534 Phosphorylation
K2543 Ubiquitination
Y2548 Phosphorylation
S2554 Phosphorylation
S2557 Phosphorylation
S2561 Phosphorylation
S2562 Phosphorylation
S2567 Phosphorylation
S2569 Phosphorylation
T2571 Phosphorylation
C2573 S-Nitrosylation
S2576 Phosphorylation
S2577 Phosphorylation
T2625 Phosphorylation
Y2726 Phosphorylation
K2736 Acetylation
K2784 Ubiquitination
K2791 Ubiquitination
K2830 Ubiquitination
Y2839 Phosphorylation
K2884 Acetylation
K2927 Acetylation
K2929 Acetylation

Research Backgrounds

Function:

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.

PTMs:

Phosphorylated by TTK; which is required for localization in centrosome.

Subcellular Location:

Cytoplasm. Nucleus. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea.

Subunit Structure:

Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF.

Family&Domains:

Belongs to the TACC family.

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