Mael Antibody - #DF13687
| Product: | Mael Antibody |
| Catalog: | DF13687 |
| Description: | Rabbit polyclonal antibody to Mael |
| Application: | WB |
| Reactivity: | Human |
| Prediction: | Pig, Horse, Rabbit, Dog |
| Mol.Wt.: | 49kDa; 49kD(Calculated). |
| Uniprot: | Q96JY0 |
| RRID: | AB_2846706 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13687, RRID:AB_2846706.
Fold/Unfold
cancer/testis antigen 128; CT128; FLJ14904; mael; MAEL_HUMAN; maelstrom homolog (Drosophila); Maelstrom homolog; OTTHUMP00000032344; Protein maelstrom homolog; RP11-102C16.1;
Immunogens
Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter.
- Q96JY0 MAEL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPNRKASRNAYYFFVQEKIPELRRRGLPVARVADAIPYCSSDWALLREEEKEKYAEMAREWRAAQGKDPGPSEKQKPVFTPLRRPGMLVPKQNVSPPDMSALSLKGDQALLGGIFYFLNIFSHGELPPHCEQRFLPCEIGCVKYSLQEGIMADFHSFINPGEIPRGFRFHCQAASDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLTVEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSVTPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLSPYMSQKDGYKSFSSLS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96JY0 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y11 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| T194 | Phosphorylation | Uniprot | |
| T370 | Phosphorylation | Uniprot | |
| Y375 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot |
Research Backgrounds
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).
Cytoplasm. Nucleus.
Note: Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity).
Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter.
Interacts with SMARCB1, SIN3B and DDX4. Interacts with piRNA-associated proteins TDRD1, PIWIL1 and PIWIL2 (By similarity). Interacts with TEX19 (By similarity).
Belongs to the maelstrom family.
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