Hippocalcin Antibody - #DF13752
| Product: | Hippocalcin Antibody |
| Catalog: | DF13752 |
| Description: | Rabbit polyclonal antibody to Hippocalcin |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| Mol.Wt.: | 22kDa, 18 kDa; 22kD(Calculated). |
| Uniprot: | P84074 |
| RRID: | AB_2846771 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13752, RRID:AB_2846771.
Fold/Unfold
BDR 2; BDR2; Calcium binding protein BDR 2; Calcium binding protein BDR2; Calcium-binding protein BDR-2; HPCA; HPCA_HUMAN; Neuron specific calcium binding protein hippocalcin; Neuron-specific calcium-binding protein hippocalcin; P23K;
Immunogens
- P84074 HPCA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P84074 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K50 | Ubiquitination | Uniprot | |
| Y52 | Phosphorylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| Y115 | Phosphorylation | Uniprot | |
| Y129 | Phosphorylation | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot |
Research Backgrounds
Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity).
Myristoylation facilitates association with membranes.
Cytoplasm>Cytosol. Membrane>Peripheral membrane protein.
Note: Association with membranes is calcium-dependent (By similarity). Enriched in the perinuclear region, probably at the trans Golgi network in response to calcium (PubMed:28398555).
Brain specific.
Oligomer; oligomerization is calcium-dependent. May interact with the voltage-dependent P/Q- and N-type calcium channels CACNA1A and CACNA1B.
Binds 3 calcium via EF-hand domains. The cryptic EF-hand 1 does not bind calcium.
Belongs to the recoverin family.
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