SCN3B Antibody - #DF13794

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Product: SCN3B Antibody
Catalog: DF13794
Description: Rabbit polyclonal antibody to SCN3B
Application: IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 25kD; 25kD(Calculated).
Uniprot: Q9NY72

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
SCN3B Antibody detects endogenous levels of total SCN3B.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

1110001K16Rik; 4833414B02Rik; HSA243396; KIAA1158; MGC136997; MGC80155; Scn3b; SCN3B_HUMAN; SCNB3; Sodium channel subunit beta-3; Sodium channel, beta 3 subunit; sodium channel, voltage-gated, type III, beta;

Immunogens

Immunogen:

A synthesized peptide derived from Human SCN3B.

Uniprot:

Q9NY72(SCN3B_HUMAN) >>Visit HPA database.

Gene(ID):
SCN3B(55800)
Expression:
Q9NY72 SCN3B_HUMAN:

Expressed in the atrium.

Sequence:
MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE

Research Backgrounds

Function:

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).

Subcellular Location:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in the atrium.

Subunit Structure:

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity).

Family&Domains:

Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.

Restrictive clause

 

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