STOM Antibody - #DF13948
| Product: | STOM Antibody |
| Catalog: | DF13948 |
| Description: | Rabbit polyclonal antibody to STOM |
| Application: | ELISA(peptide) |
| Reactivity: | Human, Mouse, Rat |
| Mol.Wt.: | 32kD; 32kD(Calculated). |
| Uniprot: | P27105 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
BND7; EPB7; EPB72; Erythrocyte band 7 integral membrane protein; Erythrocyte membrane protein band 7.2 (stomatin); Erythrocyte surface protein band 7.2; Protein 7.2b; STOM; STOM_HUMAN; Stomatin;
Immunogens
A synthesized peptide derived from Human STOM.
- P27105 STOM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAEKRHTRDSEAQRLPDSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG
Research Backgrounds
Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cell membrane>Lipid-anchor>Cytoplasmic side. Membrane raft. Melanosome. Cytoplasmic vesicle.
Note: Localizes to juxtanuclear structure probably derived from the Golgi apparatus (PubMed:9243190). Colocalizes with cortical actin microfilaments at small plasma membrane protrusions (PubMed:9243190). Associates with alpha-granular lipid rafts (PubMed:12130500). Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles (PubMed:12130500). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).
Detected in erythrocytes (at protein level). Widely expressed.
Homodimer and higher order homooligomer. The homodimer is banana-shaped. Interacts with ASIC1, ASIC2 and ASIC3 (By similarity). Interacts with LANCL1. Interacts with SLC2A1 and SLC4A1. Identified in large complexes with SLC40A1, SLC14A1, SLC29A1 and AQP1. Interacts with STOML1; may redistribute STOM from the plasma membrane to late endosomes.
Belongs to the band 7/mec-2 family.
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