Kv1.8 Antibody | Affinity Biosciences

IF/ICC

1/1

Kv1.8 Antibody - DF13986 staining Hela cells by IF/ICC.

Product:	Kv1.8 Antibody
Catalog:	DF13986
Description:	Rabbit polyclonal antibody to Kv1.8
Application:	IF/ICC
Reactivity:	Human, Mouse, Rat
Mol.Wt.:	58kD; 58kD(Calculated).
Uniprot:	Q16322

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Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

Size	Price	Inventory
100ul	$280	In stock
200ul	$350	In stock

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Related Downloads

MS Report

HPLC Report

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human,Mouse,Rat

Clonality:

Polyclonal

Specificity:

Kv1.8 Antibody detects endogenous levels of total Kv1.8.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

Cyclic GMP gated potassium channel; KCA10_HUMAN; Kcn 1; Kcn1; KCNA 10; KCNA10; Kv1.8; Potassium voltage gated channel shaker related subfamily member 10; Potassium voltage gated channel subfamily A member 10; Potassium voltage-gated channel subfamily A member 10; Voltage gated potassium channel subunit Kv1.8; Voltage-gated potassium channel subunit Kv1.8;

Immunogens

Immunogen:

A synthesized peptide derived from Human Kv1.8.

Uniprot:

Q16322(KCA10_HUMAN) >>Visit HPA database.

Gene(ID):

KCNA10(3744)

Expression:

Q16322 KCA10_HUMAN:

Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells.

Sequence:

Q16322 KCA10_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK

Research Backgrounds

Q16322_KCA10_HUMAN

Function:

Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.

Subcellular Location:

Membrane>Multi-pass membrane protein.

Tissue Specificity:

Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells.

Subunit Structure:

Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP.

Family&Domains:

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily.

Restrictive clause

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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Kv1.8 Antibody - #DF13986