MLC1 Antibody - #DF14138

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Product: MLC1 Antibody
Catalog: DF14138
Description: Rabbit polyclonal antibody to MLC1
Application: WB IHC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 41kD(Calculated).
Uniprot: Q15049

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
MLC1 Antibody detects endogenous levels of total MLC1.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

KIAA0027; LVM; Megalencephalic leukoencephalopathy with subcortical cysts 1; Membrane protein MLC1; MLC; MLC1; MLC1_HUMAN; VL; WKL1;

Immunogens

Immunogen:

A synthesized peptide derived from Human MLC1.

Uniprot:

Q15049(MLC1_HUMAN) >>Visit HPA database.

Gene(ID):
MLC1(23209)
Expression:
Q15049 MLC1_HUMAN:

Expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus.

Sequence:
MTQEPFREELAYDRMPTLERGRQDPASYAPDAKPSDLQLSKRLPPCFSHKTWVFSVLMGSCLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFAVTTTCLIWFGCKLVLNPSAININFNLILLLLLELLMAATVIIAARSSEEDCKKKKGSMSDSANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACFPSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSIMRIVEMFKDYPPAIKPSYDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSARLQGASWDTQNGPQERLAGEVARSPLKEFDKEKAWRAVVVQMAQ

Research Backgrounds

Function:

Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.

Subcellular Location:

Membrane>Multi-pass membrane protein. Cell membrane. Cytoplasm>Perinuclear region. Endoplasmic reticulum.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus.

Subunit Structure:

Interacts with ATP1B1. Part of a complex containing ATP1B1, TRPV4, AQP4 and HEPACAM.

Restrictive clause

 

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