TMEM59 Antibody - #DF14154
| Product: | TMEM59 Antibody |
| Catalog: | DF14154 |
| Description: | Rabbit polyclonal antibody to TMEM59 |
| Application: | WB ELISA(peptide) |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 36kD(Calculated). |
| Uniprot: | Q9BXS4 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
C1orf8; HSPC001; Liver membrane-bound protein; TMEM59; TMEM59 transmembrane protein 59; TMM59_HUMAN; Transmembrane protein 59;
Immunogens
A synthesized peptide derived from Human TMEM59.
- Q9BXS4 TMM59_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHTYPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQLPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEPTNLRESSLSKMSYLQMRNSQAHRNFLEDGESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHSEI
Research Backgrounds
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
N-glycosylated.
Late endosome membrane>Single-pass type I membrane protein. Lysosome membrane>Single-pass type I membrane protein. Cell membrane>Single-pass type I membrane protein. Golgi apparatus membrane>Single-pass type I membrane protein.
Note: Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded.
Interacts with ATG16L1 (via WD repeats).
The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy.
Belongs to the TMEM59 family.
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