ZC3H12D Antibody - #DF14171

Product: ZC3H12D Antibody
Catalog: DF14171
Description: Rabbit polyclonal antibody to ZC3H12D
Application: ELISA(peptide)
Reactivity: Human
Mol.Wt.: 55~70kD; 58kD(Calculated).
Uniprot: A2A288

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
ZC3H12D Antibody detects endogenous levels of total ZC3H12D.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

C6orf95; ZC3H12D; FLJ00361; FLJ46041; MCP induced protein 4; MCP-induced protein 4; MCPIP4; p34; Probable ribonuclease ZC3H12D; TFL; Transformed follicular lymphoma; Tumor suppressor TFL; ZC12D_HUMAN; ZC3H12D; Zinc finger CCCH domain containing protein 12D; Zinc finger CCCH domain-containing protein 12D;

Immunogens

Immunogen:

A synthesized peptide derived from Human ZC3H12D.

Uniprot:

A2A288(ZC12D_HUMAN) >>Visit HPA database.

Gene(ID):
ZC3H12D(340152)
Expression:
A2A288 ZC12D_HUMAN:

Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.

Sequence:
MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTGSRPGALEHPAAPRLVPRGSCGVPDSAQRGPGTALEEDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAVDWFRDRGHTYIKVFVPSWRKDPPRADTPIREQHVLAELERQAVLVYTPSRKVHGKRLVCYDDRYIVKVAYEQDGVIVSNDNYRDLQSENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRHGPSLSNFLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYHPERPHHAQLAVADELRAKTGARPGAGAEEQRPPRAPGGSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLAFSDDLGPLGPPLPVPACSLTPRLGGPDWVSAGGRVPGPLSLPSPESQFSPGDLPPPPGLQLQPRGEHRPRDLHGDLLSPRRPPDDPWARPPRSDRFPGRSVWAEPAWGDGATGGLSVYATEDDEGDARARARIALYSVFPRDQVDRVMAAFPELSDLARLILLVQRCQSAGAPLGKP

Research Backgrounds

Function:

May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages. Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation.

Subcellular Location:

Cytoplasm>P-body.
Note: Colocalizes with ZC3H12A in GW bodies (GWBs) (PubMed:26134560).

Cytoplasm.
Note: Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.

Cytoplasm. Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.

Subunit Structure:

Interacts with ZC3H12A.

Family&Domains:

Belongs to the ZC3H12 family.

Restrictive clause

 

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