ORMDL3 Antibody - #DF14231

(2)  
Product: ORMDL3 Antibody
Catalog: DF14231
Description: Rabbit polyclonal antibody to ORMDL3
Application: WB IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 17kD; 17kD(Calculated).
Uniprot: Q8N138

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
ORMDL3 Antibody detects endogenous levels of total ORMDL3.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ORM1 (S. cerevisiae)-like 3; ORM1-like 3 (S. cerevisiae); ORM1-like 3; ORM1-like protein 3; ORMDL sphingolipid biosynthesis regulator 3; Ormdl3; ORML3_HUMAN; OTTHUMP00000164334;

Immunogens

Immunogen:

A synthesized peptide derived from Human ORMDL3.

Uniprot:

Q8N138(ORML3_HUMAN) >>Visit HPA database.

Gene(ID):
ORMDL3(94103)
Expression:
Q8N138 ORML3_HUMAN:

Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus.

Sequence:
MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHNMGMYIFLHTVKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYDQIHFVLNTVSLMSVLIPKLPQLHGVRIFGINKY

Research Backgrounds

Function:

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

Subcellular Location:

Endoplasmic reticulum membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus.

Subunit Structure:

Interacts with SPTLC1.

Family&Domains:

Belongs to the ORM family.

Restrictive clause

 

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