HVCN1 Antibody - #DF14252

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Product: HVCN1 Antibody
Catalog: DF14252
Description: Rabbit polyclonal antibody to HVCN1
Application: IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 32kD; 32kD(Calculated).
Uniprot: Q96D96

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
HVCN1 Antibody detects endogenous levels of total HVCN1.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

HV 1; HV1; HVCN 1; HVCN1; HVCN1_HUMAN; Hydrogen voltage gated channel 1; Hydrogen voltage-gated channel 1; Voltage gated hydrogen channel 1; Voltage sensor domain only protein; Voltage sensor domain-only protein; Voltage-gated hydrogen channel 1; VSOP;

Immunogens

Immunogen:

A synthesized peptide derived from Human HVCN1.

Uniprot:

Q96D96(HVCN1_HUMAN) >>Visit HPA database.

Gene(ID):
HVCN1(84329)
Expression:
Q96D96 HVCN1_HUMAN:

Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.

Sequence:
MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN

Research Backgrounds

Function:

Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.

PTMs:

Phosphorylation may enhance channel gating.

Subcellular Location:

Membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein.
Note: Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.

Subunit Structure:

Homodimer.

Family&Domains:

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain.

The C-terminal coiled coil region mediates homodimerization and cooperative channel gating. It is essential for normal subcellular localization.

Belongs to the hydrogen channel family.

Restrictive clause

 

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